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Any discoloration, unusual odor, excessive powdering, or tablets that appear to be breaking down or sticking together may indicate degradation and the medication should not be used

This is why some of the medications can be dosed just once weekly, and why patients benefit from the consistent blood-sugar-lowering and appetite-suppressing effects

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It should be kept away from strong chelators (such as high levels of EDTA and related sequestrants), reducing sugars, thiol-bearing actives, and high concentrations of direct acids (for example ascorbic acid or alpha-hydroxy acids at low pH), all of which can compete for the copper center or disrupt the peptide-metal bond and shift the characteristic blue color toward brown or colorless degradation products