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Normal background C57 male mice treated with MT-II showed no significant alteration in social behavioral metrics
Potent GH pulse characteristics differ meaningfully between the two compounds
The work was supported by a Diabetes UK RD Lawrence Fellowship to Dr Reshma Ramracheya, a Novo Nordisk University of Oxford postdoctoral fellowship to Dr Claudia Guida and an OXION Wellcome Trust studentship to Miss Joely Kellard
Microsomes were prepared by sonication of 10 8 cells, removal of debris by centrifugation at 10,000 g for 15 min, and subsequent centrifugation of the resulting supernatant at 100,000 g for 60 min
Sudden discontinuation can lead to rapid weight regain and potential metabolic disturbances, which can undermine the progress made during treatment
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