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They should typically be avoided in individuals who: Have a personal or family history of medullary thyroid cancer Have multiple endocrine neoplasia syndrome type 2 (MEN2) Have a history of pancreatitis Are pregnant or breastfeeding Have severe gastrointestinal disease such as gastroparesis This is why a thorough medical evaluation is essential before starting treatment

Sources [edit] Phillips Exeter Academy in New Hampshire: A Historical Sketch

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Dedicated urate-lowering therapy such as allopurinol or febuxostat remains the mainstay treatment for hyperuricaemia and gout, in line with NICE guidance

Most air-conditioned homes stay well below 86 degrees