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PI3K/Akt/mTOR + MAPK/ERK Activates both the metabolic (PI3K/Akt/mTOR - protein synthesis, glucose uptake) and proliferative (MAPK/ERK) IGF-1 signalling cascades

Although some research has been done on BPC-157, the data can only be considered preliminary

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In the regulation of gene expression, HMGA2 activates GPX4 expression at the transcriptional and translational levels by increasing the methylation of H3K4 and the acetylation of H3K27, thereby inhibiting the production of ROS and promoting the GSH

The following secondary antibodies were used: Alexa Fluor 555-labelled donkey anti-rabbit IgG (H+L) (#A0453, Beyotime, Shanghai, China, 1:200), horseradish peroxidase (HRP)-labelled goat anti-rabbit IgG (H+L) (#GB23303-1, Servicebio, 1:8000), HRP-labelled goat anti-mouse IgG (H+L) (#GB23301, Servicebio, 1:8000), and HRP-conjugated goat anti-rabbit IgG (#D110,058, Sangon Biotech, 1:8000)