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Advantage : Semaglutide Summary and Verdict# Orforglipron represents a potential paradigm shift as the first oral non-peptide GLP-1 agonist without fasting restrictions, and it demonstrated superiority over oral semaglutide in the head-to-head ACHIEVE-3 trial for both HbA1c and weight loss

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A collaborative effort between Northwestern University and University of Illinois teams, the trial is now enrolling patients with hemangiosarcoma

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If reduced weight loss occurs despite continued use, increasing the dose is not advised