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However, Vpr also possesses DDR-inhibitory properties, antagonizing essential DSB repair mechanisms like HR and NHEJ 100

IGF-1 displays more binding sites for SHP2 (a phosphatase related to growth) and seems more prone to recruit Cbl [121] (an E3 ligase that targets the receptor for ubiquitination and destruction) and thus may explain a different regulatory mechanism not mediated by serine phosphorylation, and thus not so sensitive to metabolic derangements

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Alpha-lipoic acid/R-ALA- is an antioxidant and it stimulates the enzyme involved in the synthesis of glutathione