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17 Similarly, in a meta-analysis of 14 RCTs in T2DM patients conducted by Liu et al, tirzepatide was shown to provide superior HbA1c reduction and improved metabolic outcomes compared to placebo, insulin, and all other GLP-1 RAs at all doses examined

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This makes it hard for researchers to separate out this factor to determine what actually causes the reduced heart risks

This citation highlights deficiencies in process validation and is another core concept in quality drug manufacturing

The rising global prevalence of T2DM and obesity makes understanding the full range of benefits and risks associated with GLP-1 RAs essential for optimizing treatment strategies in these populations