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In research models, elevated NNMT activity has been associated with: lower NAD levels, with downstream effects on mitochondrial energy production

This finding is encouraging, as it suggests 5-Amino-1MQ works by altering metabolic function rather than suppressing hunger

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In addition, nicotinamide, the primary NNMT substrate 95,96 , is broken down by Lactobacillus arabinosis into nicotinic acid and ammonia 56