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Common Causes of Peptide Impurities Solid-phase peptide synthesis errors Incomplete deprotection reactions Amino acid racemization Aggregation and degradation Regulatory guidelines usually require identification of impurities present at 0.10% relative abundance in peptide drug substances

This is one of the most frustrating aspects for patients who thought they had adjusted to the medication

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In some individuals, the effects may resemble a condition called gastroparesis, where the stomach empties too slowly, leading to discomfort, poor appetite, or even vomiting

"Novo Nordisk announces FDA approval of label update for Rybelsus (semaglutide) allowing use as a first-line option for adults with type 2 diabetes" (Press release)