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ROS comprises both free and non-free radicals derived from oxygen atoms, including superoxide anion (O 2 - ), hydrogen peroxide (H 2 O 2 ), hydroxyl radicals (OH ), and singlet oxygen ( 1 O 2 ) [4]

Microglia can be artificially activated by LPS, which induces a switch from a protective to pro-inflammatory state with the production of IL-12, TNF, NO, superoxide anions, and peroxynitrite (H 2 O 2 ), causing motor neuron degeneration and exacerbation of disease progression in fALS mice [124126]

It is also neuroprotective and has favourable benefits for central nervous system disorders

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