Unlike leucine and arginine, SAMTOR directly binds and activates GATOR1 but does not inhibit GATOR2, which is upstream of GATOR1 in this pathway
Indeed, with respect to diabetes, several mitochondrial diseases manifest with diabetic complications such as mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) and maternally inherited diabetes and deafness (MIDD)
While supplements like glutathione tablets are popular, they can have side effects and may not always be the best option, especially since it has limited bioavailability due to its rapid degeneration
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Perez-Montes DE, Oca A, Pellitero S, Puig-Domingo M