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Answer: The best injection site for a B12 shot can depend on personal comfort and ease of access

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A recent meta-analysis of 12 observational studies found that higher dietary intake of vitamin B 12 was associated with a 23% lower risk of depression compared to lower intakes, but stratifying the data revealed a significant protective association in females, not in males (99)

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Beginning at 300mcg allows assessment of response without overshooting the necessary dose