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Typical strategies mainly focus on developing high-performance nanocatalysts and increasing intracellular reactants (such as H 2 O 2 and iron ions) based on the Fenton reaction of nano-DDS [198, 200]

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A narrative review concluded that the practice is controversial because there are no standardized dosing protocols and nearly onethird of patients report adverse effects, ranging from mild gastrointestinal symptoms to liver dysfunction and lifethreatening allergic reactions

With increased accumulation of lipid peroxides, the dye shifts its fluorescence from red (low peroxide levels) to green (high peroxide levels)