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Discussion The results of this systematic review showed that glutamine supplementation has a potential effect on improving fasting plasma glucose [17, 18, 22, 25, 28, 29, 31, 32], postprandial blood glucose [14, 21, 26, 27, 30], and significant increases in insulin production and incretin hormones such as GIP and GLP-1 [18, 26, 27, 29, 30, 33]