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Tirzepatide operates through a fundamentally different mechanism: it activates GLP-1 and GIP receptors in the pancreas, gut, and brain to slow gastric emptying, reduce hunger signals, and improve insulin sensitivity

doi: 10.1111/j.1751-9861.2008.00033.x 429 MorrisGAndersonGMaesM

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Retatrutide is an investigational triple agonist that targets three incretin and metabolic receptors simultaneously: GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and glucagon receptors