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doi: 10.1023/A:1010635131228 185 LiXZhangDVatnerDFGoedekeLHirabaraSMZhangYet al

In contrast to PD-L1-mediated T-cell dysfunction induced by glutamine limitation, DON and its prodrug JHU-083 skew CD8(+) T cells toward a highly activated, persistent, and proliferative phenotype, thereby facilitating immunogenic cancer cell death 58,149,150 (Fig

This delayed gastric emptying is particularly important for glycemic control and weight reduction, as it prolongs the sensation of fullness and reduces postprandial glucose excursions

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