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These proliferating cells produce significantly more O and H 2 O 2 than their normal epithelial and stromal counterparts (108, 112)
181 Further, the activity of G6PD is also repressed by aspirin casing acetylation of G6PD to decrease the activity of G6PD and the generation of NADPH, and by RRx-001, a novel clinical-stage chemosensitizer and radiosensitizer, which exerts antiproliferative effects in human tumor cells
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