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Inhibition of miRNA binding improved cardiac function and restored mitochondrial fatty acid oxidation in animal models, thus highlighting a novel potential therapy for heart failure (36)

Human data are limited to pharmacokinetic and safety studies, not controlled hypertrophy trials, so direct extrapolation from rodent models requires caution

During host cell infection, CoVs trigger an imbalance involving increased ROS production and reduced antioxidant host responses, thereby leading to increased redox stress, reduced antiviral host responses, and increased virus-induced inflammation and apoptosis, ultimately causing cell and tissue damage and end-organ disease 3

Oxalate formation from glyoxal in erythrocytes

This includes leaky gut, adrenal fatigue , insomnia, and heart disease