Data from the deCODE study are available in ref
Mechanism Avg % weight loss (placebo subtracted) Dosing Side effects Cost Semaglutide GLP-1 receptor agonist : (increases insulin secretion, suppresses appetite, enhances satiety, slows gastric emptying) STEP 1 14.9% (68 weeks) STEP 5 (120 weeks): -16.5% ~1517% average sustained loss 20% loss in ~17% of users 2.4mg weekly Nausea (44%) Diarrhea (30%) Vomiting (24%) Constipation (23%) Headache, fatigue Varies widely but generally the cheaper of the two
Rather it is a reaction to the toxins produced by the microbes
When mast cells are activated in response to progesterone, the resulting histamine surge helps explain many of the hallmark features of APD, including: Hives (urticaria) caused by histamine-induced blood vessel dilation Intense itching (pruritus) driven by histamine signaling in the skin Angioedema , or deeper swelling beneath the skin and mucous membranes Asthma-like symptoms or shortness of breath , due to histamines effects on airway smooth muscle This mast cellhistamine connection also clarifies why treatments that target allergic pathways are often effective in APD, even though progesterone is a hormone rather than a classic allergen
Red flags to watch for No COA available