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Intramuscular and intravenous delivery bypasses the gastrointestinal tract, achieving significantly higher bioavailability than oral supplementation, making injectable micronutrients a clinically effective option for patients with confirmed or suspected deficiency, malabsorption conditions, or chronic illness

About 75% had gastrointestinal side effects, but few discontinued treatment

This dual modulation likely explains the neuroprotective effects in animal models and the neuropsychiatric side effects some users report at higher doses