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Embodiment 2 [0034] N-protected-L-histidine (6.20g, 0.01mol) was added to the reaction flask, thionyl chloride (7.14g, 0.06mmol) was heated to reflux, N,N-dimethylacetamide (30mL) was added, Control the temperature and reflux
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Fasting BG levels were then measured once a day for five days before treatment and rats were considered diabetic when at least three out of five fasting BG measurements, taken over the course of five days, fell between 130200 mg/dL
The target temperature range is incredibly important
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