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While Tirzepatide acts as a dual GIP and GLP-1 receptor agonist, Retatrutide expands on this mechanism by adding glucagon receptor activity

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Gong N, Xiao Q, Zhu B, Zhang CY, Wang YC, Fan H et al (2014) Activation of spinal glucagon-like peptide-1 receptors specifically suppresses pain hypersensitivity

If the product is going to work for you, this is typically when users report more noticeable effects on cravings and appetite

Evolution of receptors for peptides similar to glucagon