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The results suggested that abdominal surgery and intestinal manipulation may lead to a marked inhibition of the contractile responses of gastric smooth muscle to acetylcholine and electrical field stimulation
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Rotenone treated in vitro PD model showed impairment of lysosomal functions due to decreased NAD + /NADH and Sirt1 expression ( In a study, extracellular S has been found to upregulate Sirt3 and Sirt5 but downregulate Sirt1 ( Pharmacological activation and inhibition of Sirts have shown protective effects against apoptotic cell death in PD models
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Instead, we took advantage of three amino acid substitutions (E505Q, T527M, and K573P
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