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Contraindications include known hypersensitivity to any component of the injection (including cobalt hypersensitivity), a history of severe reactions to thiamine/pyridoxine/cobalamin injections, and Lebers hereditary optic neuropathy (for B12-containing products)

Pregnancy and breastfeeding represent absolute contraindications based on precautionary principles

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Magi et al., 2021

doi: 10.1080/21505594.2019.1685640 40 UrsiniF.MaiorinoM.Brigelius-FloheR.AumannK