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NF-B is a key regulator of apoptosis, immunity, aging, and inflammation due to its role in the expression of proinflammatory genes, including cytokines, chemokines, and adhesion molecules.34 In the present study, the absence of elevated NF-B, TNF-, and IL-6 levels in melatonin- and glutathione-treated groups suggests potential modulation of inflammatory responses by these agents

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Management includes eating smaller meals, avoiding high-fat foods, staying hydrated, and gradual dose titration as recommended in UK prescribing guidance

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