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Acknowledgements Funding This review and the article processing charges were funded by Eli Lilly Australia
The two routes have different absorption and bioavailability profiles in published research models
This is the first step toward developing that knowledge, which will require large-scale, carefully controlled clinical trials." Rasgon is a member of the Stanford Neurosciences Institute
In its response [15], the ACOG concluded that available studies show no clear evidence that proves a direct relationship between the prudent use of APAP during any trimester and fetal developmental issues. The ACOG further concluded that physicians should not change clinical practice until definitive prospective research is done. Considering the ACOG response, it is important to note that evidence of APAP inducing neurodevelopmental problems during the prenatal period is concerning but limited [2,16,17]
