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Research on glutathione spans hepatic detoxification (it is a required cofactor for glutathione-S-transferase enzymes that conjugate and clear xenobiotics and heavy metals), mitochondrial protection, and immune cell function, where intracellular glutathione status directly influences T-lymphocyte proliferation and cytokine production
The TRX/TRXR system catalyzes the shift of disulfide-thiol reaction equilibrium toward thiolated products, which might facilitate reduction of the disulfide bonds of SARS-CoV-2 as well as ACE2
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If there is any hormonal advantage, it would almost certainly be in the context of an individualized protocol involving lifestyle, diet, and evidence-based medical treatment
Niemann-pick C1-like 1 (NPC1L1) protein in intestinal and hepatic cholesterol transport
