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J Health Econ Outcomes Res

Reduced MTHFR activity reduced methionine regeneration reduced SAM production reduced methylation capacity across all SAM-dependent methyltransferase reactions consequences that propagate through epigenetics, neurotransmitter metabolism, creatine synthesis, phosphatidylcholine production, and the broader biochemistry that SAM sustains

Treatment outcomes may be affected by under- or over-dosing as a result of improper mixing

Cancer stem cells (CSCs) are a subpopulation within solid tumors that exhibit resistance to conventional chemotherapy

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