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However, if you notice any of the following, reach out to your provider: A firm lump, swelling, or visible bulge under the skin that doesnt resolve within 12 weeks Persistent redness, warmth, or pain at the injection site Significant bruising that doesnt resolve An unexplained change in how well your medication seems to be working, such as appetite changes or inconsistent blood sugar control Any signs of an allergic reaction, such as hives, swelling beyond the injection site, or difficulty breathing