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The most common causes include B12 supplementation (particularly injections), liver disease releasing stored B12, haematological disorders increasing B12-binding proteins, and chronic kidney disease reducing B12 excretion
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However, persistently high serum B12 levels warrant medical investigation, as they may indicate liver disease, kidney dysfunction, or haematological disorders rather than simple overconsumption
People who have problems absorbing vitamin B12 may eventually suffer from pernicious anemia
It means the effect is primarily local concentrated in the GI tract, where the peptide is in direct contact with the tissue it needs to repair
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