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CB-5083, an inhibitor of P97, suppresses osteosarcoma growth and stem cell properties by altering protein homeostasis
Unintended skin lightening or darkening can occur if the cream is not applied evenly or if it reacts differently with certain skin types
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Mechanistic investigations revealed that PTX resistance was primarily mediated by EV-derived VDAC1 through the AMPK/mTOR pathway, which involved activation of general autophagy and mitophagy
GSH acts by scavenging reactive oxygen species (ROS) and chelating intracellular zinc (Zn), whose dysregulation exacerbates neuronal injury and contributes to ischemic cascades (10)
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