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1 Introduction Cystic fibrosis (CF), caused by mutations in the cystic fibrosis conductance regulator ( CFTR ) gene, is the most common rare disease affecting the Caucasian population, with an incidence of 2,5003,500 newborns (Bobadilla et al., 2002)

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Larraufie P, Roberts GP, McGavigan AK, Kay RG, Li J, Leiter A, et al

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3.7 Cardiovascular effects In a GWAS, the genetic GIP receptor variant, E354Q, and the risk of cardiovascular diseases are nominally associated (112), and also, carriers of E354Q have been associated with lower risk of coronary artery disease (113)