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The FLOW trial (N=3,533), published in the New England Journal of Medicine in 2024, showed that semaglutide 1.0 mg reduced the composite kidney endpoint by 24% in patients with type 2 diabetes and chronic kidney disease compared to placebo [8], but the trial population was closely monitored
This study identified a small molecule that activates GSDMD without cleavage, which induces cancer cell pyroptosis and stimulates antitumour immunity
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