nrf2 and glutathione NRF2-mediated pathway of synthesis. The expression of nrf2 glutathione synthesis Concurrent regulation

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Dosing is extrapolated from preclinical models [1] [6]

EGCG possesses well-documented antioxidant and anti-inflammatory activities but is limited by poor stability and bioavailability [16, 17]

protection against arrhythmias

Although AD and VaD share common vascular risk factors, the contribution of small artery disease to VaD pathogenesis may be greater than that of AD [120].In fact, studies have found that neuropathic changes can be evident 20 years before the onset of dementia and that there is a substantial neuronal loss in the MCI stage, which is considered a transitional state before the onset of dementia [121]