Fatigue with Mounjaro may result from reduced caloric intake due to decreased appetite, blood glucose fluctuations, gastrointestinal side effects causing dehydration, or the body's metabolic adaptation to weight loss and improved glycaemic control
The peptide's unique mechanism of action involves modulation of the nitric oxide system, upregulation of critical growth factors (VEGF, EGF, FGF), activation of the FAK-paxillin pathway, and interaction with GABAergic neurotransmission
Avoid drinking large quantities during meals or immediately before/after, as this can make you feel overly full
For others, GLP-1 medication offers the best pathway to consistent metabolic improvement
doi: 10.1371/journal.pone.0179538 76 StanleyTLChenCYBranchKLMakimuraHGrinspoonSK