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Over 24 hours at room temperature, NAD + showed tendency to increase by approximately 25% and NADH by 125% from the baseline at collection, while NADP + remained stable and NADPH levels decreased 69% (Supplementary Figure 1a-f)

Although the underlying mechanism for these gender effects is not known, some of the differences have been attributed to the levels of sex hormones and their receptors 76

However, significant color changes, cloudiness, or particles indicate degradation

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