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The body does not seem to adapt to it in a way that reduces effectiveness over time

This bacteriostatic rather than bactericidal preservative action maintains solution sterility between multiple vial access events and the defining practical advantage of Bacteriostatic Water over unpreserved Sterile Water for Injection, which must be used immediately upon vial entry or discarded to prevent microbial contamination

This distinction matters enormously for long-term use, where indiscriminate inflammation suppression can compromise immune function and healing capacity