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Glutathione depletion induced by c-Myc downregulation triggers apoptosis on treatment with alkylating agents

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In our model the computed value of GSH transport out of the cell (Table 4) is V cGSHb = 1152 and the rates of Cys, Gly, and Glut import are also high (Table 4), although we assume that 10% per hour of the amino acids in the blood are lost to non-liver cells and an additional 25% of Cys is lost by conversion to cystine

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However, one common factor crops up in many sleep-deprived people oxidative stress