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Sitagliptin Add-on Therapy in Patients with Type 2 Diabetes Inadequately Controlled on Metformin Alone A total of 701 patients with type 2 diabetes participated in a 24-week, randomized, double-blind, placebo-controlled study designed to assess the efficacy of sitagliptin in combination with metformin
The points below are drawn from smaller studies, case reports, and personal accounts, so they should be seen as anecdotal rather than proven risks
Because of the substantial amounts of brain glutathione and its rapid turnover under homeostatic control, we hypothesized that glutathione is a relevant reservoir of glutamate, and could influence synaptic excitability
Gastrointestinal effects such as nausea, early satiety, and changes in bowel habits are common, though typically transient and improved with gradual dose titration [30]
