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NBDHEX binds the GSTP1-1 H-site and forms a complex with GSH, inactivating the enzyme (Figs

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Severe calorie restriction in perimenopause can actually make things worse by: Further decreasing metabolic rate (adaptive thermogenesis) Increasing cortisol (chronic stress response) Promoting muscle loss over fat loss Disrupting already-irregular hormone patterns Ive seen women eating 1200 calories and doing intense cardio six days per week, completely exhausted and still gaining weight

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Protocols commonly describe waiting at least 30 minutes after injection before eating, and avoiding food for 2 hours before injection for maximum effect