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In an oxidative ER environment, activated ERO1 generates disulfide bonds by consuming O 2 in the presence of flavin cofactors, which are then passed to the protein for folding via PDI (Wang et al., 2014)
In particular, vitamin B12 deficiency may play a role in hair loss
This is why we saw BAC peaking around the 90-minute mark in our study, but impairment rising far more slowly and persisting a lot longer
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