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In the ATTAIN-MAINTAIN trial, 205 patients taking tirzepatide and 171 patients taking semaglutide were randomized to take orforglipron or placebo (no active drug) daily for a year
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Endothelial GLP-1 (Glucagon-like peptide-1) receptor mediates cardiovascular protection by liraglutide in mice with experimental arterial hypertension
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