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This is always a clinical decision, but some patterns have emerged in the way providers describe their prescribing preferences: Tirzepatide tends to be preferred for patients seeking maximum weight loss, patients with type 2 diabetes (where the dual mechanism helps glycemic control), and patients who have not responded adequately to semaglutide

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The IRA creates a specific procurement dynamic for the patent cliff: drugs on the negotiation list that also face LOE within the negotiation period present a dual pricing event