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Discontinuation in trials: retatrutide trial discontinuation due to adverse events was 6-10% across the higher-dose arms meaningful but lower than the dose-related side-effect profile would suggest, which indicates most participants tolerated the protocol

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While this might not establish an ergothioneine causeand-effect relationship (e.g., lower ergothioneine levels could be a consequence of brain cell loss), it underscores the potential significance of this compound

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doi: 10.1002/hep.32598 69

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Both activate AMPK, but through distinct mechanisms: metformin inhibits complex I of the mitochondrial electron transport chain, raising the cellular AMP:ATP ratio and thereby activating AMPK indirectly

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