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Given 40-60% nasal bioavailability compared to 80-95% for injection, equivalent nasal doses would be approximately 400-1000mcg to achieve similar systemic levels
2b), in agreement with our previous characterization of this BBB model [40]
Effect of selenium on glutathione metabolism: induction of -glutamylcysteine synthetase and glutathione reductase in the rat liver
Exclusion criteria were as follows: intervention not strictly followed
In targeted therapy, GSH depletion prevents redox-driven adaptive resistance to PI3K/AKT/mTOR, MAPK, and KRAS inhibitors, intensifying oxidative stress and restoring drug sensitivity
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