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Elevated cAMP levels subsequently activate protein kinase A (PKA), a central kinase that may phosphorylate key downstream proteins
Firkins SA, Yates J, Shukla N, et al
If the mutation is present in just one of the MTHFR genes, it is heterozygous for the MTHFR mutation
This selectivity matters: elevated IGF-1 accelerates skeletal growth in children but has minimal impact on fracture healing or bone density restoration in adults because mature osteoblasts respond primarily to local paracrine signals, not circulating growth factors
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