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The fundamental distinction lies in their mechanism: sulfonylureas provide continuous insulin stimulation (carrying intrinsic hypoglycaemia risk), whilst incretin mimetics offer glucose-responsive action with additional metabolic benefits beyond glycaemic control
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Angiogenesis Seiwerth et al
LIN28A can activate AR via c-mycregulation and promotes malignancy of ER-/Her2 + BC [63], thus providing strong evidence that curcumin can directly or indirectly interact with androgen signaling pathways and can affect tumor progression by regulating androgen signaling
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