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Using animal models, the researchers found that GLP-1 drugs improve blood flow to the heart after a heart attack by activating potassium channels, which relax pericytes

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These effects were more noticeable in longer trials and when ALA was combined with dietary changes.29 A 2020 dose-response meta-analysis confirmed small but statistically significant reductions in weight and BMI across 18+ randomized controlled trials.30 However, waist circumference (WC) a marker of central obesity showed no consistent change, and the benefit appeared greater in women and with longer treatment durations

Membranes were probed using antibodies to FoxO1 (1:2500, 18592-1AP, Proteintech, Chicago, IL, USA), SOD2 (1:6000, 66474-1lg, Proteintech, Chicago, IL, USA), NOX4 (1:600, 14347-1-AP, Proteintech, Chicago, IL, USA), and -actin (1:2000, AM10218-400, Abgent) as the primary antibodies