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Zhao J, Zhang S, Yang T, Zeng Z, Huang Z, Liu Q, Wang X, Leach J, Leung H, Liu B (2015) Global transcriptional profiling of a cold-tolerant rice variety under moderate cold stress reveals different cold stress response mechanisms

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In short, the gut microbiota influences brain function via the regulation of neurotransmitters and neurotrophic factors, maintenance of intestinal barrier and tight junction integrity, activation of enteric sensory afferents, production of bacterial metabolites, and modulation of mucosal immune responses [22]

The primary way it achieves skin brightening is by inhibiting the enzyme tyrosinase, which is crucial in melanin synthesis