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It requires a complete review of clinical data, toxicology data, manufacturing processes, finished product formulations, therapeutic indications, and administration routes
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10.3390/ijms21062164 56 RamadanA.AfifiN.YassinN
46 In rat model of OA, the nuclear localization of Nrf2 enhanced by Transient Receptor Potential Vanilloid (TRPV)-1 activation via the Ca 2+ /calmodulin-dependent protein kinase II (CaMKII)/Nrf2 signaling pathway inhibited M1 macrophage polarization in synovium, thus attenuating OA progression
In addition to genetic endothelial induction, transplantation-based vascularization has provided key mechanistic insight into kidney organoid maturation
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